We described the distributions of major causes of death in patients diagnosed with NHL. The study analyzed the primary cause but not the direct cause. All causes of death were categorized into NHL-specific and non-NHL specific causes, with the latter one being further classified into 1 infectious and parasitic diseases, 2 diseases of the circulatory system, 3 diseases of the respiratory system, and 4 other causes.
NHL-specific causes included progress, relapse and complication of NHL according to the medical history. Distributions of patients were grouped by basic clinical information listed above. Overall survival OS was defined as the period from clinical diagnosis to death. Survival curves were drawn using the Kaplan—Meier method. This study included participants who died during the follow-up period.
All patients were Asian. The average age was The mean duration from diagnosis until death was Except for 8 patients who abandoned treatment, others all received chemotherapy in our department. Other variables showed no significant difference between groups. Mortality from NHL was the most common independent cause of death, accounting for The other common causes were diseases of the circulatory and respiratory systems.
The results presented in Table 2 only include causes that were found to be significant in this study. The patients were divided into two groups: death attributed to NHL and death attributed to other causes Table 3. Secondly, patients were further classified into four groups: 1 infectious and parasitic diseases, 2 diseases of the circulatory system, 3 diseases of the respiratory system and 4 other causes Table 4.
For patients diagnosed with T-cell lymphoma, the cumulative incidence of the death rate attributed to NHL was much higher Figure 2. On the contrary, patients diagnosed with B-cell lymphoma had greater risks for other causes rather than NHL. A significant difference was shown between the groups that were diagnosed later than compared to their counterparts; patients in this group had a higher probability of death from other causes.
The age-standardized incidence rate of NHL increased from to , while the mortality rate increased from to and remained stable. Patients with B-cell lymphoma had a longer survival time, in accordance with a study in primary intestinal NHL. Patients with B symptoms had worse survival, probobaly due to abnormal endogenous cytokines.
This retrospective cohort study demonstrated that the most common cause of death among patients with NHL was NHL, followed by diseases of the circulatory system and respiratory system. This finding is similar to that of previous studies that attempted to determine the cause of death in cancer patients. Zaorsky et al conducted an analysis of 28 cancers and found that patients with lung, pancreatic, and brain cancer were most likely to die of primary cancer.
The competing-risks regression model was constructed to evaluate the relationship between variables and cause-specific failures, 27 the sub-distribution hazard rate of the specific causes and cumulative incidence of those causes were shown. The results showed that patients diagnosed with T-cell lymphoma are more likely to die of NHL, probably due to the subtype and treatment regimen. In cases, in which the patients were diagnosed before , the cause of death was more likely attributed to diseases of the circulatory system, respiratory system, infection and parasitic diseases, and rare causes.
This is probably due to the supplement of electronic medical record data and a better follow-up system in recent years. Limitations exist in this study. We only included patients with specific death dates and recorded causes, which may have led to selection bias. Due to the retrospective nature of the study, some information may have been missing. Moreover, this is a single-center study, which may limit the generalizability of the study due to regional or racial differences among patients.
Furthermore, the number of deaths attributed to non-NHL diseases was relatively small, probably resulted in statistics deviations in uncommon causes.
Lastly, autopsies information was not included because of the lack of cases. In conclusion, T-cell lymphoma, poor ECOG performance, and the presence of B symptoms were found to be the primary factors leading to a poor prognosis. This cohort study revealed that the most common cause of death among patients with NHL is NHL, followed by diseases of the circulatory and respiratory systems.
Patients diagnosed with T-cell lymphoma are more likely to die of NHL rather than any other cause. Moreover, patients exhibiting B symptoms on admission were more likely to die of diseases of the circulatory system. More efforts should be made in implementing a comprehensive prognostic evaluation and treatment plan in preventing high-risk factors in NHL patients.
We would like to show gratitude to all members in the oncology department of the First Affiliated Hospital of Zhengzhou University. All authors contributed to data analysis, drafting or revising the article, gave final approval of the version to be published, and agree to be accountable for all aspects of the work.
National Center for Biotechnology Information , U. Journal List Cancer Manag Res v. About Cancer generously supported by Dangoor Education since Questions about cancer?
Call freephone 9 to 5 Monday to Friday or email us. Skip to main content. Home About cancer Non-Hodgkin lymphoma Survival. Survival depends on many factors. No one can tell you exactly how long you will live. Your doctor can give you more information about your own outlook prognosis. You can also talk about this with the Cancer Research UK nurses on freephone , from 9am to 5pm, Monday to Friday. Where this information comes from. Cancer survival by stage at diagnosis for England, Office for National Statistics These statistics are for net survival.
Follicular lymphoma. Follicular lymphoma is the most common type of low grade lymphoma. Marginal zone lymphoma.
Marginal zone lymphomas are slow growing B cell lymphomas. There are different types of marginal zone lymphomas. These are: extranodal marginal zone B-cell lymphoma, also known as mucosa-associated lymphoid tissue MALT lymphoma nodal marginal zone B-cell lymphoma splenic marginal zone B-cell lymphoma Extranodal marginal zone B-cell lymphomas have a slightly better outcome than the other types.
Diffuse large B cell lymphoma. Diffuse large B cell lymphoma is the most common type of high grade lymphoma. Burkitt lymphoma. Burkitt lymphoma is a less common type of high grade lymphoma which can grow quite quickly.
Find more detailed statistics about non-Hodgkin lymphoma. Find out how to join a clinical trial. Related links. What is non-Hodgkin lymphoma? Find out who gets non Hodgkin lymphoma, where it starts and how common it is. Berteau tweeted in December that Aschoff had pneumonia and was being treated for a presumed diagnosis of HLH , or hemophagocytic lymphohistiocytosis, which is an immune system disease. All of this combined is what led to his very rapid decline those last few days, and ultimately his passing," she tweeted on Wednesday.
Hill added that generally, young healthy patients diagnosed with aggressive non-Hodgkin lymphoma can be treated effectively with chemotherapy. Sara G. IE 11 is not supported. For an optimal experience visit our site on another browser.
Politics Covid U. News World Opinion Business.
0コメント